Which statement best contrasts transcription initiation in prokaryotes and eukaryotes?

• A. In prokaryotes, transcription requires a complex of RNA polymerase II and transcription factors to recognize a TATA box.
• B. Eukaryotes transcribe in the cytoplasm using a single RNA polymerase without processing.
• C. Prokaryotes rely on a single RNA polymerase with a sigma factor recognizing -35 and -10 promoter elements; transcription occurs in the cytoplasm.
• D. Eukaryotes use RNA polymerase II with general transcription factors and a promoter that does not require enhancers.

Answer: (C)